Sodium Methoxide → HCID 23151322, compound

HRID 2386971Notes

Reaction equation

HRID 2386971 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([CH3:16])[N:10]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][CH2:26][N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[CH:19][C:18]=1[O:32][CH2:33][CH2:34][F:35])[C:9]2=[O:36])=[O:5])C.C[O-].[Na+]>CO>[F:35][CH2:34][CH2:33][O:32][C:18]1[CH:19]=[C:20]([O:23][CH2:24][CH2:25][CH2:26][N:27]2[CH2:31][CH2:30][CH2:29][CH2:28]2)[CH:21]=[CH:22][C:17]=1[N:10]1[C:9](=[O:36])[C:8]2[C:13](=[CH:14][CH:15]=[C:6]([C:4]([O:3][CH3:1])=[O:5])[CH:7]=2)[N:12]=[C:11]1[CH3:16]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 86600244HCID 86600244, compound

Product 1

HCID 23151322HCID 23151322, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-ethoxycarbonyl-3-(2-fluoroethoxy-4-[3-(1-pyrrolidinyl)propoxy]-phenyl)-2-methyl-4(3H)-quinazolinone synthesized in Example 205 was treated by sodium methoxide in dry methanol, and the title compound was thus obtained.

Sources & evidence

ORD record
ord-bb806d06e4be4e25a1008b952a0dcc99
Source dataset
uspto-grants-2012_09
Patent number
US08268842B2

Reaction notes

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