2-Chloro-4-aminopyrimidine → N4-{2-[(4-aminopyrimidin-2-yl)amino]ethyl}-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidine-2,4-diamine

Participants

Reaction Steps

The product of Example 4B (67 mg, 0.196 mmol) and 6-amino-2-chloropyrimidine (33 mg, 0.254 mmol) were treated under the conditions of Example 1F to afford the title compound. 1H NMR (300 MHz, CDCl3) δ ppm 7.87 (d, J=5.55 Hz, 1H) 7.62-7.68 (m, 1H) 7.28-7.37 (m, 2H) 7.14-7.21 (m, 1H) 5.80 (d, J=5.55 Hz, 1H) 5.30-5.39 (m, 1H) 4.72 (s, 2H) 4.61 (s, 2H) 3.57-3.73 (m, 4H) 2.53 (t, J=6.94 Hz, 2H) 2.15 (t, J=6.35 Hz, 2H) 1.94-2.08 (m, 2H); MS (ESI+) m/z 363.0 (M+H)+.

Provenance & Evidence