2-Amino-4,6-dichloropyrimidine → N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-6-chloropyrimidine-2,4-diamine

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Reaction Steps

The product of Example 1E (250 mg, 1.11 mmol) and 2-amino-4,6-dichloropyrimidine (201 mg, 1.23 mmol) were treated under the conditions described in Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.31-3.41 (m, 4H) 5.72 (d, J=5.95 Hz, 1H) 5.75 (s, 1H) 5.85 (s, 2H) 6.40 (s, 2H) 6.85 (s, 1H) 7.21 (s, 1H) 7.61 (d, J=5.55 Hz, 1H); MS (ESI+) m/z 280.9 (M+H)+.

Provenance & Evidence