5-Chloro-2-methoxyphenylboronic acid → N4-{2-[(2-aminopyrimidin-4-yl)amino]ethyl}-6-(5-chloro-2-methoxyphenyl)pyrimidine-2,4-diamine

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Reaction Steps

The product of Example 6A (50 mg, 0.178 mmol) and 5-chloro-2-methoxyphenyl boronic acid (37 mg, 0.196 mmol) were treated under the conditions described in Example 6B to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.85 (d, J=2.78 Hz, 1H) 7.61 (d, J=5.55 Hz, 1H) 7.39 (dd, J=8.92, 2.97 Hz, 1H) 7.12 (d, J=8.73 Hz, 1H) 7.02 (s, 1H) 6.88 (s, 1H) 6.42 (s, 1H) 5.97 (s, 2H) 5.86 (s, 2H) 5.74 (d, 1H) 3.82 (s, 3H) 3.34-3.43 (m, 4H); MS (ESI+) m/z 387.2 (M+H)+.

Provenance & Evidence