3-[3-[(2Z)-2-[1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-(oxomethylidene)pyrazol-4-ylidene]hydrazinyl]-2-hydroxyphenyl]benzoic acid → bis(2-aminoethanol);3-[3-[(2Z)-2-[1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-(oxomethylidene)pyrazol-4-ylidene]hydrazinyl]-2-hydroxyphenyl]benzoic acid

Participants

Reaction Steps

(Z)-2′-hydroxy-3′-[N′-(1-indan-5-yl-3-methyl-5-carbonyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-biphenyl-3-carboxylic acid 1j (454 mg, 1.0 mmol) was dissolved in 16 mL of tetrahydrofuran. The reaction mixture was added with ethanolamine (143 mg, 2.35 mmol), and stirred for 3 hours. The mixture was filtered, the filter cake was washed with tetrahydrofuran (2 mL×3), and the solid was dried in vacuo to obtain the title compound (Z)-2′-hydroxy-3′-[N′-(1-indan-5-yl-3-methyl-5-carbonyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-biphenyl-3-carboxylic acid bis-(ethanolamine) 1 (553 mg, yield: 96.0%) as a dark red solid.

Provenance & Evidence