Nitric Acid → HCID 86223897, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Bis-(2,2,2-trifluoro-ethyl)-pyridine 1-oxide (2.65 g, 10.22 mmol)was dissolved in H2SO4 (4 mL) and cooled to 0° C. HNO3 (3.2 mL) was added slowly and after the addition was complete the reaction mixture was heated to 90° C. for 2 hours. The mixture was poured into ice, made basic with 15% NaOH and extracted with CH2Cl2. The organic layers were washed with brine, dried over Na2SO4 and concentrated to a red oil (2.72 g, 81%). 1H NMR (400 MHz, CDCl3): δ 3.95 (t, J=10.1 Hz, 4 H), 8.31 (s, 2 H).

Provenance & Evidence