反应详情

5-(3-Amino-2-methoxy-phenyl)-furan-2-carboxylic acid 4f (2.79 g, 11.97 mmol) was dissolved in 25 mL of dichloromethane followed by dropwise addition of boron tribromide (23.9 mL, 2.0 M). The reaction mixture was reacted at room temperature for 1 hour. The mixture was concentrated under reduced pressure after 5 mL of methanol was added. The residue was diluted with 100 mL of ethyl acetate and stirred for 1 hour. Then the mixture was filtered and the filter cake was dried to obtain the title compound 5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide 4g (1.24 g, yield 47.2%) as a yellow solid.

1. customThe reaction mixture was reacted at room temperature for 1 hour
2. concentrationThe mixture was concentrated under reduced pressure after 5 mL of methanol
3. additionwas added
4. additionThe residue was diluted with 100 mL of ethyl acetate
5. filtrationThen the mixture was filtered
6. customthe filter cake was dried