Methanol → Methyl 4-bromo-2-ethylbenzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-bromo-2-ethyl-benzoic acid (1.35 g, 5.89 mmol) in MeOH (40 mL) was added H2SO4 (1 drop). The mixture was stirred at 90° C. for 48 hours, at which time the volatiles were removed in vacuo. The residue was dissolved in Et2O, washed with satd NaHCO3 and brine, dried over MgSO4, and concentrated to a clear oil (1.01 g, 70%). 1H NMR (300 MHz, CDCl3): δ 1.22 (t, J=7.5 Hz, 3 H), 2.95 (q, J=7.5 Hz, 2 H), 3.87 (s, 3 H), 7.36 (dd, J=8.3, 2.1 Hz, 1 H), 7.42 (d, J=2.1 Hz, 1 H), 7.72 (d, J=8.3 Hz, 1 H).

Provenance & Evidence