HCID 58764009, compound → HCID 58764116, compound

HRID 2387091Notes

Reaction equation

HRID 2387091 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([CH2:12][CH2:13][C:14]2([CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:19][C:18](=[O:20])[CH2:17][C:16](=[O:21])[O:15]2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].C1(C2(CCC3C=CC(C(OC)=O)=C(F)C=3)CC(=O)CC(=O)O2)CCCC1>>[Cl:1][C:2]1[CH:11]=[C:10]([CH2:12][CH2:13][C:14]2([CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:19][C:18](=[O:20])[CH2:17][C:16](=[O:21])[O:15]2)[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 58764009HCID 58764009, compoundHCID 58764067HCID 58764067, compound

Product 1

HCID 58764116HCID 58764116, compound

Procedure

The title compound was prepared analogously to example B(6): where methyl 2-chloro-4-[2-(2-cyclopentyl-4,6-dioxotetrahydro-2H-pyran-2-yl)ethyl]benzoate (example B(7)) was substituted in place of methyl 4-[2-(2-cyclopentyl-4,6-dioxotetrahydro-2H-pyran-2-yl)ethyl]-2-fluorobenzoate in that example. 1H NMR (300 MHz, CDCl3): δ 1.38-2.30 (m, 11 H), 2.78-3.15 (m, 6 H), 7.10 (s, 1 H), 7.19 (d, J=1.58 Hz, 1 H), 7.62 (d, J=1.56 Hz, 1 H) 12.30 (s, 1 H).

Sources & evidence

ORD record
ord-437a161de134441aa18f36766abbdc99
Source dataset
uspto-grants-2012_09
Patent number
US08268835B2

Reaction notes

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