Acetylacetone → HCID 178426284, compound

HRID 2387114Notes

Reaction equation

HRID 2387114 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:7])[NH:5][N:6]=1.[CH3:8][C:9](=O)[CH2:10][C:11](=O)[CH3:12]>C(O)(=O)C>[CH3:8][C:9]1[CH:10]=[C:11]([CH3:12])[N:6]2[N:5]=[C:4]([OH:7])[N:3]=[C:2]2[N:1]=1

Participants

4

Reactant 2

HCID 31261AcetylacetoneHCID 1354819695-Amino-1,2-dihydro-3H-1,2,4-triazol-3-one

Product 1

HCID 178426284HCID 178426284, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 5-amino-2,4-dihydro-3H-1,2,4-triazol-3-one (29 g, 0.29 mol) in glacial acetic acid (140 mL) was added pentane-2,4-dione (29 g, 0.29 mol) and the solution was refluxed for 8 hours. The reaction mixture was concentrated under reduced pressure to afford a yellow solid. The solid was filtered and washed with ethanol (200 mL) to give the product (42 g, 80%).

Workup

  1. temperaturethe solution was refluxed for 8 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto afford a yellow solid
  4. filtrationThe solid was filtered
  5. washwashed with ethanol (200 mL)

Sources & evidence

ORD record
ord-5f1bc41830f343a98fe730384d8cb52e
Source dataset
uspto-grants-2012_09
Patent number
US08268835B2

Reaction notes

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