Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | Ethyl 3-oxovalerate | HCID 78656 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178436950 | HCID 178436950 | 97.5% |
Reaction Steps
Methylhydrazine (31.6 g, 0.687 mol) in methanol (100 mL) was added dropwise to a solution of ethyl 3-oxopentanoate (100 g, 0.694 mol) in methanol (280 mL) over a period of 45 min, during which time the temperature increased to 45° C. The reaction mixture was then allowed to stir at room temperature overnight and then evaporated, affording 84.5 g (97%) of the crude title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08268835B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-6c49ae3b7cf44b78a1c72d99e79f8578 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
