Pyridine → HCID 44236425, compound

HRID 2387199Notes

Reaction equation

HRID 2387199 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[C:10]([CH:23]=[O:24])=[N:11][C:12]([C:15]2[CH:20]=[C:19]([NH2:21])[CH:18]=[CH:17][C:16]=2[CH3:22])=[CH:13][N:14]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[NH2:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([NH:21][C:5](=[O:7])[CH3:6])[CH:18]=[CH:17][C:16]=2[CH3:22])=[N:11][C:10]=1[C:23]([C:27]1[CH:26]=[N:25][CH:30]=[CH:29][CH:28]=1)=[O:24]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 87523458HCID 87523458, compound

Product 1

HCID 44236425HCID 44236425, compound

Procedure

Acetic anhydride (19.7 ml, 0.21 mmol) is added to solution of Example 110 (48.5 mg, 0.15 mmol) in pyridine (1.5 ml), and the resulting solution is stirred at room temperature for 2 hours. The solvent is removed in vacuo and trituration with methanol and diethyl ether yields the title compound as a yellow solid; MS m/z 348 [M+H]+

Workup

  1. customThe solvent is removed in vacuo and trituration with methanol and diethyl ether

Sources & evidence

ORD record
ord-e4a7ceed97cb4611a094efa5aa5387a8
Source dataset
uspto-grants-2012_09
Patent number
US08268834B2

Reaction notes

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