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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2387207Generated: October 25, 2026

2-Methyl-5-(morpholin-4-ylsulphonyl)benzeneboronic acid → 3-Amino-6-[2-methyl-5-(morpholine-4-sulfonyl)-phenyl]-pyrazine-2-carboxylic acid methoxy-methyl amide

https://huagongshe.com/reaction/2387207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-5-(morpholin-4-ylsulphonyl)benzeneboronic acidHCID 44119554—
Reactant3-Amino-6-(3,4-dichloro-phenyl)-pyrazine-2-carboxylic acid methoxy-methyl amideHCID 86634542—
Product3-Amino-6-[2-methyl-5-(morpholine-4-sulfonyl)-phenyl]-pyrazine-2-carboxylic acid methoxy-methyl amideHCID 86634543—

Reaction Steps

This compound is prepared in an analogous manner to intermediate B substituting 3,4 dichlorophenyl boronic acid with 2-methyl-5-(N-morpholinylsulfonyl) phenyl boronic acid in step 2. The title compound is obtained as an off-white solid. [M+H]+ 422.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08268834B2
Source datasetuspto-grants-2012_09
ORD IDord-d102bace775e4209b0eab820f6a1c22b
Source noteuspto-grants-2012_09