Diisopropylethylamine → HCID 68505027, compound

Participants

Reaction Steps

To a solution of 5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic acid (Preparative Example 2) (1 eq), TBTU (1.2 eq), and DIPEA (1.5 eq) in DMF (0.18M) was added methyl N-(2,2-diethoxyethyl)glycinate (1 eq) (prepared as described in Synthesis 2002, 2, 242-252), and the mixture was stirred at RT for 2 h. The reaction was diluted with EtOAc, washed sequentially with 1N HCl, sat. aq. NaHCO3 solution, and then with brine. The organic layers were dried (Na2SO4), filtered and concentrated and concentrated under reduced pressure. MS (ES) C23H30FN3O6 required: 463, found: 464 (M+H)+; 486 (M+Na)+.

Provenance & Evidence