Water → N-(2,4-Difluorophenyl)propane-1-sulfonamide

Participants

Reaction Steps

To 2,4-difluoro-phenylamine (8, 11.8 g, 91.4 mmol) in dichloromethane (110 mL) were added pyridine (8.13 mL, 100 mmol) and propane-1-sulfonyl chloride (11.3 mL. 100 mmol). The reaction was stirred overnight. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with 1M HCl solution and brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography eluting with 10% ethyl acetate in hexane to give a solid (9, 19.98 g, 93%). MS (ESI) [M−H+]−=234.1.

Provenance & Evidence