Water → HCID 59774846, compound

Participants

Reaction Steps

To (2,4-dichloro-phenyl)-(5-phenoxy-1H-pyrrolo[9,3-b]pyridin-3-yl)-methanol (33, 30 mg, 0.078 mmol) in acetonitrile (8 mL), triethylsilane (1 mL, 7 mmol) and trifluoroacetic acid (0.5 mL, 7 mmol) were added. The reaction solution was heated to reflux for 4 hours. Then, the reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, water, and brine, dried over anhydrous magnesium sulfate, filtrated and concentrated. The crude material was suspended in acetonitrile (1˜2 mL). The precipitated material was collected with vacuum filtration to provide the compound (P-0037, 13 mg, 45%). MS (ESI) [M+H+]+=369.1 and 371.1.

Provenance & Evidence