Hydrochloric Acid → HCID 58026180, compound

Participants

Reaction Steps

To a solution of 7.1 g of 2-((S)-1,1-dimethyl-3-triethylsilanyloxy-3-trifluoromethylhex-5-ynyl)-5-fluorobenzamide (15.7 mmol) in 80 mL of MeOH was added 400 mL of HCl (4 N in dioxane, 1.6 mol). The reaction was stirred for 2 hours at room temperature. The volatiles were concentrated in vacuo and 500 mL of water was added. The reaction mixture was then extracted with ethyl acetate, dried over sodium sulfate, and concentrated in vacuo to afford 5.2 g (100%) of 5-fluoro-2-((S)-3-hydroxy-1,1-dimethyl-3-trifluoromethylhex-5-ynyl)benzamide.

Provenance & Evidence