反应详情

温度

70 °C

To a stirred solution of (R)-2-[2-(2-methylphenyl)-2-methylpropyl]-2-trifluoromethyloxirane (37 g, 0.143 mmol) in 500 mL of anhydrous CCl4 at room temperature was added N-bromosuccinimide (26 g, 0.146 mmol). The reaction mixture was heated to 70° C. and the reaction flask was irradiated with a UV light (500 W) for 1 hour. The reaction mixture, after cooling to normal room temperature, was washed with saturated aqueous sodium bicarbonate solution followed by water, dried over anhydrous sodium sulfate, and the solvent evaporated in vacuo to give (R)-2-[2-(2-bromomethylphenyl)-2-methylpropyl]-2-trifluoromethyloxirane as a light yellow oil (46.6 g, 81%; ˜85% pure) which was used for the next reaction without purification.

1. customthe reaction flask was irradiated with a UV light (500 W) for 1 hour
2. temperatureThe reaction mixture, after cooling to normal room temperature
3. washwas washed with saturated aqueous sodium bicarbonate solution
4. dry with materialdried over anhydrous sodium sulfate
5. customthe solvent evaporated in vacuo