Sodium Hydroxide → HCID 58026123, compound

Participants

Reaction Steps

To a solution of 150 mg (0.47 mmol) of 6-benzo[b]thiophen-7-yl-6-methyl-4-trifluoromethylhept-1-yn-4-ol in 15 mL of dichloromethane was added 280 mg (˜1.2 mmol) of m-chloroperoxybenzoic acid. After stirring at room temperature for 2.5 hours, the reaction mixture was poured into 30 mL of 1N aqueous NaOH solution and extracted with two 30 mL portions of dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. The crude 6-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-7-yl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol was used without further purification.

Provenance & Evidence