Hydrochloric Acid → HCID 59293394, compound

Participants

Reaction Steps

A solution of 1-(1-(2,2-dimethoxyethyl)-1H-indazol-5-yl)-4-phenethylpyridin-2(1H)-one (1.77 g, 4.39 mmol) in THF (20 mL) was treated with aqueous HCl (20 mL, 2.0 M). The solution was heated at 60° for 18 h, allowed to cool and then treated with H2O (50 mL). The mixture was extracted with EtOAc (3×100 mL), dried with Na2SO4, filtered and concentrated to give the title compound (1.72 g, 98%) as an orange solid: ESI MS m/z 390 [M+H]+.

Provenance & Evidence