(E)-2-Methoxy-4-styrylpyridine → 2-Methoxy-4-phenethylpyridine

HRID 2387510노트

반응식

HRID 2387510 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1>CO>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1

참가 물질

3

반응물 1

HCID 57950306(E)-2-Methoxy-4-styrylpyridine

생성물 1

HCID 579504422-Methoxy-4-phenethylpyridine수율 98.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

(E)-2-Methoxy-4-styrylpyridine (22.15 g, 104.8 mmol) was dissolved in MeOH (400 mL) and degassed with a nitrogen stream for 10 minutes. Palladium on charcoal (10%, wet, 5 g) was added and the reaction mixture was stirred under an atmosphere of hydrogen for 24 h. The reaction mixture was degassed again, and the catalyst was removed by filtration. Concentration of the filtrate provided the title compound (22 g, 98%) as a green oil: 1H NMR (500 MHz, CDCl3) δ 8.04 (d, J=5.3 Hz, 1H), 7.29-7.24 (m, 2H), 7.21-7.15 (m, 3H), δ 69-6.67 (m, 1H), 6.54 (s, 1H), 3.91 (s, 3H), 2.91-2.89 (m, 2H), 2.87-2.84 (m, 2H).

후처리

  1. customdegassed with a nitrogen stream for 10 minutes
  2. additionPalladium on charcoal (10%, wet, 5 g) was added
  3. customThe reaction mixture was degassed again
  4. customthe catalyst was removed by filtration

출처 및 근거

ORD 기록
ord-825fca2bc8ba4617bfba4825f38ea61e
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268868B2

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