3-Nitrobenzenesulfonyl chloride → HCID 59152956, compound

HRID 2387556Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][CH:10]([NH2:15])[C:9]=2[CH:8]=[N:7]1)[CH3:2].[N+:17]([C:20]1[CH:21]=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1)([O-:19])=[O:18]>>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][CH:10]([NH:15][S:26]([C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([N+:17]([O-:19])=[O:18])[CH:21]=3)(=[O:27])=[O:28])[C:9]=2[CH:8]=[N:7]1)[CH3:2]

Participants

Reactant 2

HCID 84763-Nitrobenzenesulfonyl chloride

HCID 59152911HCID 59152911, compound

Product 1

HCID 59152956HCID 59152956, compoundYield 63.6%

Procedure

Starting with (4-amino-4,5,6,7-tetrahydro-indazol-1-yl)-acetic acid ethyl ester and 3-nitro-benzenesulfonyl chloride using the method analogous to the one described above for example 1-1, [4-(3-nitro-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester (519 mg, 63.6%) was obtained as a white solid. MS cald. for C17H20N4O6S 408, obsd. (ESI+) [(M+H)+] 409.

Sources & evidence

ORD record: ord-9f49a00e53584e11b882a76cc5d469b2
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08268870B2

Reaction notes

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