HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → Tert-butyl 1-oxa-6-azaspiro[2.6]nonane-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | tert-Butyl 4-methylideneazepane-1-carboxylate | HCID 46941824 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl 1-oxa-6-azaspiro[2.6]nonane-6-carboxylate | HCID 57366410 | — |
Reaction Steps
In analogy to example 82 step 1 with 4-methylene-azepane-1-carboxylic acid tert-butyl ester (MW: 211.307, 1.73 mmol), 1.16 g sodium bicarbonate (MW: 84.01 13.8=01) and 1.36 g of 80% m-chloroperbenzoic acid (MW172.57, 6.05 mmol) in 5 ml of dichloromethane. Yield: 250 mg, 63%. MS: 228.8 (M+H)+, 127.8 (M-(CH3)3COCO) method ESI+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268812B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-400dcd084ef64a32a7b319892b49957e |
| Source note | uspto-grants-2012_09 |