Ethyl bromopyruvate → ethyl 2-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)thiazole-4-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Ethyl bromopyruvate	HCID 66144	—
Reactant	2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazole-3(2H)-carbothioamide	HCID 86608770	—
Product	ethyl 2-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)thiazole-4-carboxylate	HCID 86608779	—

Reaction Steps

Prepared from 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazole-3(2H)-carbothioamide as in Example 21, Step C, utilizing ethyl 3-bromo-2-oxopropanoate in place of tert-butyl 3-bromo-4-oxopiperidine-1-carboxylate, 57%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08268871B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-1b7e13d770cf4865a9d6bec060891a76
Source note	uspto-grants-2012_09