3-Methoxyphenol → HCID 86612399, compound

HRID 2387653Notes

Reaction equation

HRID 2387653 reaction equation
[C:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:14][O:15][C:16]1[CH:17]=[C:18](O)[CH:19]=[CH:20][CH:21]=1>>[CH3:14][O:15][C:16]1[CH:21]=[C:20]([CH:19]=[CH:18][CH:17]=1)[O:13][C@H:10]1[CH2:11][CH2:12][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

Participants

3

Reactant 2

HCID 90073-MethoxyphenolHCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 86612399HCID 86612399, compoundYield 81%

Procedure

The title compound was prepared from (R)-(−)-N-boc-3-pyrrolidinol and 3-methoxyphenol, using the same method as that described for preparation 3, as a gum in 81% yield.

Workup

  1. customthat described for preparation 3, as a gum in 81% yield

Sources & evidence

ORD record
ord-8036c83585fe4490b26b6bf3492d2b0a
Source dataset
uspto-grants-2012_09
Patent number
US08268881B2

Reaction notes

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