HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate | HCID 6544479 | — |
| Product | Ammonia | HCID 222 | — |
| Product | HCID 10826398 | HCID 10826398 | — |
Reaction Steps
The title compound was prepared from (R)-(−)-N-boc-3-pyrrolidinol and benzyl bromide, using the same method as that described for preparation 5. The crude compound was purified by column chromatography on silica gel, eluting with dichloromethane:methanol:0.88 ammonia, 95:5:0.5, to afford the desired product in 97% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268881B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-de0b5c75f2c945d6b37ddd329ed5ebe9 |
| Source note | uspto-grants-2012_09 |