Dichloromethane → HCID 519056, compound

Participants

Reaction Steps

Triethylamine (9.7 ml) and phenylacetyl chloride (7.67 ml) were added to a dichloromethane solution (50 ml) of 3-methyl-2-buten-1-ol (5 g), while the solution was stirred under cooling on ice. The obtained mixture was stirred under cooling on ice for 3 hours. Thereafter, water was added to the reaction solution, and the obtained mixture was then extracted with dichloromethane. The obtained organic layer was dried over magnesium sulfate, and was then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-heptane:ethyl acetate=1:0 to 19:1), so as to obtain the title compound (11.5 g).

Provenance & Evidence