Ethyl Acetoacetate → Ethyl 2-acetyl-3-(dimethylamino)acrylate

Participants

Reaction Steps

N,N-dimethylformamide dimethyl acetal (80.4 ml) was added dropwise to ethyl acetoacetate (63 g), and the obtained mixture was then stirred at room temperature for 14 hours. Thereafter, the reaction solution was concentrated under reduced pressure, and azeotropy with toluene was then performed three times, so as to obtain a crude title compound (89 g).

Provenance & Evidence