Methyl iodide → HCID 86664274, compound

HRID 2387744Notes

Reaction equation

HRID 2387744 reaction equation
[CH3:1]I.[Cl:3][C:4]1[N:9]=[C:8]([OH:10])[C:7]([F:11])=[CH:6][CH:5]=1>C(=O)([O-])[O-].[Ag+2].C(Cl)(Cl)Cl>[Cl:3][C:4]1[N:9]=[C:8]([O:10][CH3:1])[C:7]([F:11])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 178517805HCID 178517805, compound

Product 1

HCID 86664274HCID 86664274, compound

Reagents, catalysts & solvents 2

HCID 178418647HCID 178418647, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
40 °C

Procedure

Methyl iodide (262 ul) and silver carbonate (1.12 g) were added to a chloroform (3 ml) solution of the compound 325-1 (300 mg), and the obtained mixture was stirred at 40° C. for 5 hours. The temperature of the reaction solution was cooled to room temperature. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate=1:0 to 1:1), so as to obtain the title compound (86 mg).

Workup

  1. temperatureThe temperature of the reaction solution was cooled to room temperature
  2. filtrationThe reaction solution was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate=1:0 to 1:1)

Sources & evidence

ORD record
ord-d2355596cbad43b58184860fb32af977
Source dataset
uspto-grants-2012_09
Patent number
US08268848B2

Reaction notes

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