Pyridinium chloride → HCID 178432973, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the compound 325-3 (70 mg) and pyridine hydrochloride (367 mg) was stirred at 115° C. for 2.5 hours. The temperature of the reaction solution was returned to room temperature. Thereafter, water was added to the reaction solution, and the obtained mixture was extracted with ethyl acetate. The solvent was distilled off. The obtained residue was purified by silica gel column chromatography (n-heptane:ethyl acetate (19:1 to 0:1) to ethyl acetate:methanol (9:1)). The obtained purified product was further repurified by preparative silica gel TLC (ethyl acetate:methanol=19:1), so as to obtain the title compound (30 mg).

Provenance & Evidence