反应详情

温度

120 °C

The crude compound 326-1 (25.6 g) was dissolved in a 1.25 N sodium hydroxide aqueous solution (140 ml). Iodine (19.9 g) was added to the solution, and the obtained mixture was then stirred at 120° C. for 2 hours. The temperature of the reaction solution was returned to room temperature, and the reaction solution was then extracted with chloroform. The obtained organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, so as to obtain the title compound (14.5 g).

1. customwas returned to room temperature
2. extractionthe reaction solution was then extracted with chloroform
3. dry with materialThe obtained organic layer was dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure