Iodine → HCID 178432770, compound

HRID 2387747Notes

Reaction equation

HRID 2387747 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[I:10]I>[OH-].[Na+]>[I:10][C:5]1[C:6]([OH:8])=[N:7][C:2]([CH3:1])=[N:3][C:4]=1[CH3:9]

Participants

4

Reactant 2

HCID 807IodineHCID 178429343HCID 178429343, compound

Product 1

HCID 178432770HCID 178432770, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
120 °C

Procedure

The crude compound 326-1 (25.6 g) was dissolved in a 1.25 N sodium hydroxide aqueous solution (140 ml). Iodine (19.9 g) was added to the solution, and the obtained mixture was then stirred at 120° C. for 2 hours. The temperature of the reaction solution was returned to room temperature, and the reaction solution was then extracted with chloroform. The obtained organic layer was dried over magnesium sulfate and then concentrated under reduced pressure, so as to obtain the title compound (14.5 g).

Workup

  1. customwas returned to room temperature
  2. extractionthe reaction solution was then extracted with chloroform
  3. dry with materialThe obtained organic layer was dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-07425efa44ae4666b5f36229b1a38027
Source dataset
uspto-grants-2012_09
Patent number
US08268848B2

Reaction notes

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