HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(4-(Chloromethyl)-2-fluorobenzyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-3-fluorophenyl)methanol | HCID 66819207 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-(Chloromethyl)-2-fluorobenzyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine | HCID 68952503 | — |
Reaction Steps
Thionyl chloride (0.224 mL) was added to a solution of the product from step (v) (0.85 g) in DCM (15 mL) under nitrogen. The resulting mixture was stirred at rt for 2 h. The reaction mixture was evaporated to dryness under reduced pressure to give the subtitle compound as a yellow solid 0.85 g that was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-55aa29a76a27433b845f9af1c0c1aeb3 |
| Source note | uspto-grants-2012_09 |