HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetramethyltin → 2-Amino-4-methyl-6-(pentylamino)pyrimidine-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | 2-Amino-4-chloro-6-(pentylamino)pyrimidine-5-carbaldehyde | HCID 86633406 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Amino-4-methyl-6-(pentylamino)pyrimidine-5-carbaldehyde | HCID 86633407 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of the product from step (i) (20 g), tetramethyltin (20 ml) and tetrakis(triphenylphosphine)palladium (0) (2 g) in DMF (200 ml) was heated at 100° C. for 16 h then evaporated under reduced pressure. The residue was partitioned between EtOAc/brine, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 50-60% EtOAc/isohexane to afford the subtitle compound, 14.4 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-94cf0309bf8040cbbcc99c98360693ba |
| Source note | uspto-grants-2012_09 |