Thionyl Chloride → HCID 178433371, compound

HRID 2387856Notes

Reaction equation

HRID 2387856 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]O)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>C(Cl)Cl>[ClH:3].[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][Cl:3])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178433374HCID 178433374, compound

Product 1

HCID 178433371HCID 178433371, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (6 ml) was added to a mixture of the product from step (i) (2.38 g) in DCM (80 ml) and the mixture stirred at rt under nitrogen for 18 h. The mixture was evaporated under reduced pressure to afford the subtitle compound, used crude in next step.

Workup

  1. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-90ee13748e03428f85203fd3d144cd63
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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