Butylamine → 2-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile

HRID 2387859Notes

Reaction equation

HRID 2387859 reaction equation
CC1C=C(C)C=C(C)C=1S(O[C:14]1[C:19]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([CH2:27][C:28]#[N:29])=[CH:23][CH:22]=2)=[C:18]([CH3:30])[N:17]=[C:16]([NH2:31])[N:15]=1)(=O)=O.[CH2:32]([NH2:36])[CH2:33][CH2:34][CH3:35]>O1CCOCC1>[NH2:31][C:16]1[N:15]=[C:14]([NH:36][CH2:32][CH2:33][CH2:34][CH3:35])[C:19]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([CH2:27][C:28]#[N:29])=[CH:25][CH:26]=2)=[C:18]([CH3:30])[N:17]=1

Participants

4

Reactant 2

HCID 8007ButylamineHCID 866334092-Amino-5-(4-(cyanomethyl)benzyl)-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate

Product 1

HCID 684144282-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of the product from step (iv) (0.3 g) and butylamine (1 ml) in 1,4-dioxane (6 ml) was sealed into a microwave tube and the reaction was performed in the CEM Microwave, at 160° C. and 100 W for 1 h. The solvent was evaporated under reduced pressure and the residue used crude in the next step.

Workup

  1. customwas sealed into a microwave tube
  2. customwas performed in the CEM Microwave, at 160° C.
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6ab6c52e6f14432782cd89b42e9183f5
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

Loading…