HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Methyl 2-(benzyloxy)-4-iodobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-iodosalicylate | HCID 11380407 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-(benzyloxy)-4-iodobenzoate | HCID 66990993 | — |
Reaction Steps
A mixture of methyl 2-hydroxy-4-iodobenzoate (22.8 g), benzyl bromide (10.3 ml) and K2CO3 (22.67 g) in DMF (200 ml) was stirred at rt for 72 h. The mixture was partitioned between diethyl ether and water, the organics separated washed with water, dried and evaporated under reduced pressure to give a white solid, 29.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c14ff9b2809f484e90086b0ad46c1d20 |
| Source note | uspto-grants-2012_09 |