Carbonic acid-guanidine (1:1) → HCID 178499476, compound

HRID 2387884Notes

Reaction equation

C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[CH3:9][O:10][C:11]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([O:30][CH3:31])=[O:29])=[CH:23][C:12]=1[CH2:13][CH:14]([C:20](=O)[CH3:21])[C:15](OCC)=[O:16]>CO>[NH2:7][C:6]1[N:8]=[C:15]([OH:16])[C:14]([CH2:13][C:12]2[CH:23]=[C:24]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH:25]=[CH:26][C:11]=2[O:10][CH3:9])=[C:20]([CH3:21])[N:5]=1

Participants

Conditions

Temperature: 50 °C

Procedure

Guanidine carbonate (0.443 g) was added to a solution of the product from step (iii) (0.52 g) in MeOH (10 ml) and stirred at 50° C. for 15 h. The solvent was evaporated and the residue stirred in EtOAc (10 mL) and water (10 mL), the resulting solid was filtered off. Further product was collected by evaporation of the filtrate, the solids were combined to give the subtitle compound as a yellow solid, 0.607 g.

Workup

customThe solvent was evaporated
stirringthe residue stirred in EtOAc (10 mL)
filtrationwater (10 mL), the resulting solid was filtered off
customFurther product was collected by evaporation of the filtrate

Sources & evidence

ORD record: ord-116b534e2deb4e04a9dafe41b2ea16f0
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08268990B2

Reaction notes

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