Carbonic acid-guanidine (1:1) → HCID 178490297, compound

HRID 2387890Notes

Reaction equation

C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[C:9]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:27][CH3:28])=[C:16]([CH:26]=1)[CH2:17][CH:18]([C:23](=O)[CH3:24])[C:19](OC)=[O:20])#[N:10]>CO>[NH2:7][C:6]1[N:8]=[C:19]([OH:20])[C:18]([CH2:17][C:16]2[CH:26]=[C:12]([CH2:11][C:9]#[N:10])[CH:13]=[CH:14][C:15]=2[O:27][CH3:28])=[C:23]([CH3:24])[N:5]=1

Participants

Conditions

Temperature: 50 °C

Procedure

Guanidine carbonate (5 g) was added to a stirred solution of the product from step (i) (5.01 g) in MeOH (80 mL). The suspension was heated at 50° C. for 15 h and then the solvent evaporated under reduced pressure. The residue was diluted with water (20 mL) and diethyl ether (20 mL). The resulting precipitate was collected by filtration and the solid was dried under vacuum to give the subtitle compound as an orange solid, 2.8 g.

Workup

customthe solvent evaporated under reduced pressure
additionThe residue was diluted with water (20 mL) and diethyl ether (20 mL)
filtrationThe resulting precipitate was collected by filtration
customthe solid was dried under vacuum

Sources & evidence

ORD record: ord-103730ed96bf4b41a1bcce77fadc37dd
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08268990B2

Reaction notes

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