HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2387896Generated: November 3, 2026
Sodium methanethiolate → (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid
https://huagongshe.com/reaction/2387896
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetic acid | HCID 68953524 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid | HCID 68954538 | — |
Reaction Steps
To the product from example 30 step (v) (250 mg) in DMF (20 ml), sodium thiomethoxide (180 mg) was added and stirred at 100° C. for 16 h. The solvents were evaporated, and crude product purified by RPHPLC to give the subtitle compound as a colourless gum, 120 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08268990B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-7b59f5836a7942d4b4ca8bb0e1c2285c |
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| Source note | uspto-grants-2012_09 |
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