HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → HCID 42613746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid | HCID 68954538 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 42613746 | HCID 42613746 | — |
Reaction Steps
The product from step (i) (120 mg) was dissolved in MeOH (10 mL) and TMS-Cl (0.205 ml) was added and stirred at rt overnight. The crude product was purified by RPHPLC to give the title compound as a white solid, 35 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-73209bfd9b2b498c9c2082e77c07bf89 |
| Source note | uspto-grants-2012_09 |