3-(Methylsulfonyl)-1-propanol → 3-(Methylsulfonyl)propyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetate

HRID 2387904Notes

Reaction equation

HRID 2387904 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=2[O:24][CH3:25])=[C:4]([CH3:26])[N:3]=1.[CH3:27][S:28]([CH2:31][CH2:32][CH2:33]O)(=[O:30])=[O:29]>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23][CH2:33][CH2:32][CH2:31][S:28]([CH3:27])(=[O:30])=[O:29])=[O:22])=[CH:16][C:15]=2[O:24][CH3:25])=[C:4]([CH3:26])[N:3]=1

Participants

3

Reactant 2

HCID 2004243-(Methylsulfonyl)-1-propanolHCID 684141782-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetic acid

Product 1

HCID 426137493-(Methylsulfonyl)propyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetate

Procedure

The title compound was prepared using the method of example 89 step (vii), using the product of example 89 step (vi) (150 mg) and 3-(methylsulfonyl)propan-1-ol (116 mg), to give the title compound as a gum, 6.3 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5cade608a01345058651e51bf2953bca
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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