Hydrochloric Acid → N,N-Dimethyl-1-(2-(methylamino)ethyl)-4-phenylpiperidin-4-amine tris hydrochloride

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Reaction Steps

HCl gas was passed for 30 minutes through a solution of 9 g (1 equiv.) of tert-butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)carbamate in 600 ml of CH3Cl. The progress of the reaction was monitored by means of thin-layer chromatography (20% MeOH/CHCl3). When the reaction was complete, HCl gas was passed through for a further 30 minutes and the complete reaction was again monitored by means of thin-layer chromatography (20% MeOH/CHCl3). When the reaction was complete, the solvent was removed under reduced pressure and 7.2 g (96%) of the desired product were obtained in the form of a white solid. The free base was obtained by dissolving the hydrochloride in aqueous sodium hydroxide solution and extracting with dichloromethane.

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