Hydrochloric Acid → HCID 67368626, compound

Participants

Reaction Steps

3-[6-(Azetidin-1-yl-methyl)-1,2,3,4-tetrahydro-isoquinolin-2-yl]-azetidine-1-carboxylic acid tert-butyl ester (2.042 mmol, 2 equiv.) was dissolved in hydrogen chloride in methanol (1.25 M, 10 equiv., 16 ml) and stirred for 30 minutes at boiling temperature. After monitoring by thin-layer chromatography, the methanol was removed and the residue was dissolved in ethanol/acetone (1:5, 20 ml). The hydrochloride was precipitated with diethyl ether (50 ml), filtered, washed with diethyl ether and dried in vacuo to yield the desired product. Yield: 100%

Provenance & Evidence