Potassium Hydroxide → HCID 67356290, compound

Participants

Reaction Steps

A mixture of 3-hydroxy-3-pyridin-3-yl-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester (0.867 mmol), 1-(2-chloro-ethyl)-pyrrolidine hydrochloride (1.3 mmol, 1.5 equiv.), dry KOH powder (4.33 mmol, 5 equiv.) and catalytic amounts of 18-Crown-6 in toluene (20 ml) was heated for 16 hours at boiling temperature. The reaction mixture was diluted with ethyl acetate (25 ml) and washed with distilled water (10 ml) and saturated sodium chloride solution (10 ml). The organic phase was dried over sodium sulfate and concentrated. The crude product was then purified by column chromatography (5% MeOH in DCM). Yield: 34%

Provenance & Evidence