HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-4-(trifluoromethyl)benzoic acid → 4-(Trifluoromethyl)anthranilic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-4-(trifluoromethyl)benzoic acid | HCID 642096 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Trifluoromethyl)anthranilic acid | HCID 67869 | 92.2% |
Reaction Steps
A mixture of 2-nitro-4-(trifluoromethyl)benzoic acid (646 g, 2.75 mol) and 10% palladium on carbon (50% in water, 71 g) in MeOH (3.6 L) was allowed to stir at rt under an atmosphere of H2 (15 psi). After 3 h, TLC (DCM:MeOH 10:1) showed no remaining starting material. The mixture was filtered and the filtrate was concentrated to give 2-amino-4-(trifluoromethyl)benzoic acid (520 g, 92%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268992B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-ba928b6f92044dc8879f0dd7d2372177 |
| Source note | uspto-grants-2012_09 |