2,3-Dichloro-5-nitropyridine → HCID 68792452, compound

HRID 2388041Notes

Reaction equation

HRID 2388041 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([OH:11])[N:2]=1.Cl[C:13]1[C:18]([Cl:19])=[CH:17][C:16]([N+:20]([O-:22])=[O:21])=[CH:15][N:14]=1>>[Cl:19][C:18]1[C:13]([O:11][C:3]2[N:2]=[CH:1][C:10]3[C:5]([CH:4]=2)=[CH:6][CH:7]=[CH:8][CH:9]=3)=[N:14][CH:15]=[C:16]([N+:20]([O-:22])=[O:21])[CH:17]=1

Participants

3

Reactant 2

HCID 27631062,3-Dichloro-5-nitropyridineHCID 178515325HCID 178515325, compound

Product 1

HCID 68792452HCID 68792452, compound

Procedure

Isoquinolin-3-ol was reacted with 2,3-dichloro-5-nitro pyridine to obtain 3-(3-chloro-5-nitropyridin-2-yloxy)isoquinoline which was further converted to 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine as per the procedure described in preparation 1, step iii and iv.

Sources & evidence

ORD record
ord-512e52409a1848458bf82360f31eef92
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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