Benzenesulfonyl chloride, 2,4-dichloro- → 2,4-Dichloro-N-(5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide

HRID 2388043Notes

Reaction equation

HRID 2388043 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[Cl:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[S:28](Cl)(=[O:30])=[O:29]>>[Cl:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[S:28]([NH:19][C:4]1[CH:5]=[N:6][C:7]([O:8][C:9]2[N:10]=[CH:11][C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:2]([Cl:1])[CH:3]=1)(=[O:30])=[O:29]

Participants

3

Reactant 2

HCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 687937575-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 247589912,4-Dichloro-N-(5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide

Procedure

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per the procedure described in preparation 2) and 2,4-dichloro benzenesulfonylchloride.

Workup

  1. customobtained as per the procedure

Sources & evidence

ORD record
ord-86a754ffd4c14a1dbb13839df4319a74
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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