4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 24852357, compound

HRID 2388053Notes

Reaction equation

HRID 2388053 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[F:20][C:21]([F:33])([F:32])[C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:19][S:28]([C:25]2[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:32])[F:33])=[CH:27][CH:26]=2)(=[O:30])=[O:29])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2

Participants

3

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 687937575-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852357HCID 24852357, compound

Procedure

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 4-(trifluoromethyl)benzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-f1d415383aed4fe183a6f5b73d07f17c
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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