4-Chlorobenzenesulfonyl chloride → HCID 24852358, compound

HRID 2388054Notes

Reaction equation

HRID 2388054 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([NH:19][C:4]2[CH:5]=[N:6][C:7]([O:8][C:9]3[N:10]=[CH:11][C:12]4[C:17]([CH:18]=3)=[CH:16][CH:15]=[CH:14][CH:13]=4)=[C:2]([Cl:1])[CH:3]=2)(=[O:29])=[O:28])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 687937575-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852358HCID 24852358, compound

Procedure

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 4-chlorobenzene-1-sulfonyl chloride. 1H NMR (DMSO-d6) δ: 7.56-7.62 (m, 2H), 7.63-7.68 (m, 2H), 7.72-7.81 (m, 5H), 7.92 (d, 1H), 8.10 (d, 1H), 9.06 (s, 1H), 10.75 (s, 1H); MS (ES): 444.0 (M−1).

Sources & evidence

ORD record
ord-e1f062511cde4c698ece4f3be4da7ba7
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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