4-Chloro-2-fluorobenzene-1-sulfonyl chloride → HCID 24852359, compound

HRID 2388055Notes

Reaction equation

HRID 2388055 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[N:10]=[CH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[C:23]([F:31])[CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27]([NH:19][C:4]2[CH:5]=[N:6][C:7]([O:8][C:9]3[N:10]=[CH:11][C:12]4[C:17]([CH:18]=3)=[CH:16][CH:15]=[CH:14][CH:13]=4)=[C:2]([Cl:1])[CH:3]=2)(=[O:28])=[O:29])=[C:23]([F:31])[CH:22]=1

Participants

3

Reactant 2

HCID 27788604-Chloro-2-fluorobenzene-1-sulfonyl chlorideHCID 687937575-Chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine

Product 1

HCID 24852359HCID 24852359, compound

Procedure

The title compound was prepared by reacting 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine (obtained as per procedure described in preparation 2) and 4-chloro-2-fluorobenzene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-0d13a7ad7e9c49429c49deaee777db3a
Source dataset
uspto-grants-2012_09
Patent number
US08269010B2

Reaction notes

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